Author

Taghreed Fadhul

University of KentuckyORCID 0009-0001-1983-6735Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Molecular Biology· 3

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Organism:mouse· 3 Research Focus:benchmarking· 1 Assay:bulk RNA-seq· 1 Research Focus:differential expression· 1 Research Focus:gene regulatory network inference· 1 Organism:human· 1 Approach:statistical model· 1

Frequent Co-Authors

Samir SofticiD· 3 shared Se‐Hyung Park· 3 shared Senad DivanoviciD· 2 shared Aldons Jake LusisiD· 1 shared Alessandro BoianelliiD· 1 shared Birgit SchillingiD· 1 shared C. Ronald KahniD· 1 shared Calvin PaniD· 1 shared

Activity by Year

2023-2024 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 35 mutual co-author links

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3 shared papersMolecular Biology

Samir SofticORCID

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3 papers

Recent·Most cited

Molecular BiologybioRxivPreprintNov 26, 2024

The propensity of fructose to induce metabolic dysfunction is dependent on the baseline diet, length of the dietary exposure, and sex of the mice.

Taghreed Fadhul, Se‐Hyung Park, Heba Ali…·Samir Softic

This study shows that fructose's impact on metabolism depends on baseline diet, exposure duration, and sex in mice.

2 citations

mouseexperimental assay

𝕏 PostBluesky

Molecular BiologybioRxivPreprintAug 14, 2023

GalNAc-siRNA Mediated Knockdown of Ketohexokinase Versus Systemic, Small Molecule Inhibition of its Kinase Activity Exert Divergent Effects on Hepatic Metabolism in Mice on a HFD

Se‐Hyung Park, Taghreed Fadhul, Lindsey R. Conroy…·Samir Softic

This study compares the effects of GalNAc-siRNA-mediated KHK knockdown and small molecule KHK inhibition on hepatic metabolism in mice on a high-fat diet, finding divergent impacts on lipid metabolism and glucose tolerance.

DOI 10.1101/2023.08.14.553218

mouseexperimental assay

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Molecular BiologybioRxivPreprintJan 27, 2023

Fructose Induced KHK-C Increases ER Stress and Modulates Hepatic Transcriptome to Drive Liver Disease in Diet-Induced and Genetic Models of NAFLD.

Se‐Hyung Park, Robert Nathaniel Helsley, Taghreed Fadhul…·Samir Softic

This study shows that fructose metabolism via KHK-C increases ER stress and modulates the hepatic transcriptome, contributing to NAFLD progression in both genetic and diet-induced models.

3 citations

𝕏 PostBluesky