Marilena D’Aurelio

This study identifies lipid-mediated ER stress as a driver of muscle dysfunction in mitochondrial myopathies and shows that ceramide inhibition improves symptoms in a mouse model.

The paper develops an R package for pixel-by-pixel ratio imaging of metabolite pairs in mass spectrometry imaging, enhancing spatial contrast and revealing new tissue regions and biomarkers.

This study shows that a high fat diet improves mitochondrial cardiomyopathy in CHCHD10 mutant mice by enhancing fatty acid utilization and reducing protein aggregation.