Developmental BiologySciencePeer-reviewed
Zygotic genome activation by the totipotency pioneer factor Nr5a2
Johanna Gassler, Wataru Kobayashi, Imre Gáspár…·Kiku-e K. Tachibana
This study identifies Nr5a2 as a key activator of zygotic genome activation in mouse embryos, showing it regulates 72% of ZGA genes and is essential for development beyond the 2-cell stage.