Author

Kiku-e K. Tachibana

Institute of Molecular BiotechnologyORCID 0000-0002-6564-7484Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Developmental Biology· 2 Genomics· 1

Signature Assays, Organisms & Methods

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Research Focus:gene regulatory network inference· 3 Organism:mouse· 3 Approach:statistical model· 3 Assay:ChIP-seq· 2 Assay:DNA methylation· 1 Approach:experimental assay· 1 Assay:Hi-C· 1

Frequent Co-Authors

Adarsh MohananiD· 2 shared Johanna GassleriD· 2 shared Sabrina LadstätteriD· 2 shared Siwat RuangroengkulrithiD· 2 shared Wataru KobayashiiD· 2 shared Aleksandar LaliciD· 1 shared Antoine VallotiD· 1 shared Eda Nur ArslantasiD· 1 shared

Activity by Year

2017-2025 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 29 mutual co-author links

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2 shared papersDevelopmental Biology

Adarsh MohananORCID

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3 papers

Recent·Most cited

Feed-forward loops by NR5A2 ensure robust gene activation during pre-implantation development

Wataru Kobayashi, Siwat Ruangroengkulrith, Eda Nur Arslantas, Adarsh Mohanan, Kiku-e K. Tachibana

The paper shows NR5A2 uses feed-forward loops with KLF and GATA factors to regulate gene activation during mouse pre-implantation development.

Development · Dec 8, 2025Peer-reviewedDevelopmental Biology

Zygotic genome activation by the totipotency pioneer factor Nr5a2

Johanna Gassler, Wataru Kobayashi, Imre Gáspár, Siwat Ruangroengkulrith, Adarsh Mohanan, Laura Gómez Hernández, Pavel Kravchenko, Maximilian Kümmecke, Aleksandar Lalic, Nikita Rifel, Robert John Ashburn, Maciej Zaczek, Antoine Vallot, Laura Cuenca Rico, Sabrina Ladstätter, Kiku-e K. Tachibana

This study identifies Nr5a2 as a key activator of zygotic genome activation in mouse embryos, showing it regulates 72% of ZGA genes and is essential for development beyond the 2-cell stage.

Science · Nov 24, 2022Peer-reviewedDevelopmental Biology

A Mechanism of Cohesin-Dependent Loop Extrusion Organizes Zygotic Genome Architecture

Johanna Gassler, Hugo B. Brandão, Maxim Imakaev, Ilya M. Flyamer, Sabrina Ladstätter, Wendy A. Bickmore, Jan‐Michael Peters, Leonid A. Mirny, Kiku-e K. Tachibana

The paper shows cohesin-dependent loop extrusion organizes zygotic chromatin into loops and domains, with distinct effects on maternal and paternal genomes.

The EMBO Journal · Dec 7, 2017Peer-reviewedGenomics