Author

Lei Jia

Amgen (United States)ORCID 0000-0001-5255-3449Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

Click to filter author papers

Bioinformatics· 1 Pharmacology & Toxicology· 1

Signature Assays, Organisms & Methods

Click to filter · or open tag

Research Focus:drug response / drug discovery· 1 Organism:human· 1 Approach:mechanistic / dynamical model· 1 Research Focus:protein design· 1 Assay:protein sequence· 1 Approach:statistical model· 1

Frequent Co-Authors

Daniel K. Cashion· 1 shared Fabio BroccatelliiD· 1 shared Franco LombardoiD· 1 shared Javier L. BayloniD· 1 shared Mani JainiD· 1 shared Vijayabhaskar VeeravalliiD· 1 shared Yaxiong Sun· 1 shared

Activity by Year

2022-2024 · peak 1/yr

Co-Author Collaboration Network

7 top collaborators · 11 mutual co-author links

Click any collaborator node to inspect or filter shared papers

Focal author (center)Selected co-authorORCID co-authorUnlinked name

Curved chords = mutual co-authorship

1 shared paperPharmacology & Toxicology

Daniel K. Cashion

Mutual co-authors in cluster

Author profile →

2 papers

Recent·Most cited

Pharmacology & ToxicologyMolecular PharmaceuticsPeer-reviewedAug 13, 2024

Application of mechanistic multiparameter optimization and large scale in vitro to in vivo pharmacokinetics correlations to small molecule therapeutic projects

Fabio Broccatelli, Vijayabhaskar Veeravalli, Daniel K. Cashion…·Lei Jia

This paper applies mechanistic multiparameter optimization to drug discovery, showing it can prioritize compounds effectively for clinical trials with high accuracy.

15 citations

mechanistic / dynamical modeldrug response / drug discovery

𝕏 PostBluesky

BioinformaticsAntibody TherapeuticsPeer-reviewedJul 1, 2022

Improving antibody thermostability based on statistical analysis of sequence and structural consensus data

Lei Jia, Mani Jain, Yaxiong Sun

The paper develops a method to improve antibody thermostability by combining consensus sequence analysis with structural residue pair covariance from 3D structures.

9 citations

humanprotein sequence

𝕏 PostBluesky