Author

Mani Jain

Amgen (United States)ORCID 0000-0003-0786-3100Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Research Focus:protein design· 2 Assay:protein sequence· 2 Approach:experimental assay· 1 Organism:human· 1 Organism:mouse· 1 Approach:statistical model· 1

Frequent Co-Authors

Alexandra M. Paulk· 1 shared Brandon JewiD· 1 shared Chang C. LiuiD· 1 shared Christine Elaine TinbergiD· 1 shared CHRISTOPHER JAMES LANGMEADiD· 1 shared Debjani Bhar· 1 shared Gamze Ö. Çamdere· 1 shared Grant L. J. KelleriD· 1 shared

Activity by Year

2022-2025 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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1 shared paperSynthetic Biology

Alexandra M. Paulk

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2 papers

Recent·Most cited

Synthetic BiologybioRxivPreprintOct 4, 2025

Mapping the evolution of computationally designed protein binders

Miguel A. Alcantar, Alexandra M. Paulk, Shoeib Moradi…·Chang C. Liu

This paper evolves computationally designed protein binders using in vivo hypermutation and maps their sequence-affinity landscapes to understand affinity improvements and mutation interactions.

2 citations

mouseprotein sequence

𝕏 PostBluesky

BioinformaticsAntibody TherapeuticsPeer-reviewedJul 1, 2022

Improving antibody thermostability based on statistical analysis of sequence and structural consensus data

Lei Jia, Mani Jain, Yaxiong Sun

The paper develops a method to improve antibody thermostability by combining consensus sequence analysis with structural residue pair covariance from 3D structures.

9 citations

humanprotein sequence

𝕏 PostBluesky