Javier L. Baylon

Balanced Permeability Index is a Strong Predictor of Intestinal Absorption and Oral Bioavailability for Heterobifunctional Ligand-Directed Degraders

This study introduces BPILDD, a new metric combining size, polarity, lipophilicity, and cross-sectional area, to predict oral bioavailability of ligand-directed degraders more effectively than existing methods.

Application of mechanistic multiparameter optimization and large scale in vitro to in vivo pharmacokinetics correlations to small molecule therapeutic projects

This paper applies mechanistic multiparameter optimization to drug discovery, showing it can prioritize compounds effectively for clinical trials with high accuracy.

Balanced Permeability Index: a multi-parameter index for improved in-vitro permeability

This study introduces the Balanced Permeability Index (BPI), a multi-parameter metric that improves classification of molecular permeability and efflux, outperforming individual physicochemical properties.

PepSeA: Peptide Sequence Alignment and Visualization Tools to Enable Lead Optimization

PepSeA provides tools for peptide sequence alignment and visualization to support lead optimization in drug discovery.