Adelinde M. Uhrmacher

This paper develops a rule-based simulation model to study mitochondrial dynamics in pancreatic beta-cells and their impact on insulin secretion and mitochondrial health.

The paper develops a mechanistic model to resolve debates on how receptor trafficking and membrane organization influence Wnt/β-catenin signaling, revealing a compensatory recycling mechanism and the role of ordered domains in signalosome stability.

SIMPROV captures comprehensive provenance for simulation studies by integrating data from multiple software tools into a coherent graph.

This paper introduces an efficient simulation engine for dynamic compartmental models in cell biology, significantly improving performance over existing methods.

The paper analyzes how variant classifications in ClinVar change over time using discrete-time Markov chains to model reclassification dynamics between releases.

The paper develops a provenance ontology for simulation models of Wnt signaling and applies it to 19 models, showing how they are related through shared entities and activities.

The paper compares different computational methods for simulating cellular biochemistry and identifies discrepancies in results, emphasizing the need for critical evaluation of models.