GenomicsbioRxivPreprint
Genetic surveillance of SARS-CoV-2 Mpro reveals high sequence and structural conservation prior to the introduction of protease inhibitor Paxlovid
Jonathan T. Lee, Qingyi Yang, Alexey V. Gribenko…·Hao Li
This study analyzes SARS-CoV-2 Mpro sequences from 4.89 million genomes to assess mutation patterns and structural conservation before Paxlovid use, finding rare escape mutations and strong purifying selection.
6 citations