Author

Xikun Huang

Changping LaboratoryORCID 0000-0001-5322-9800Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:deep learning· 1 Research Focus:protein design· 1 Assay:protein structure· 1 Approach:transformer / foundation model· 1

Frequent Co-Authors

Baihui TianiD· 1 shared Di WangiD· 1 shared Hongzhun WangiD· 1 shared Jie LiniD· 1 shared Liangyue GuoiD· 1 shared Mingchen CheniD· 1 shared Qilin YuiD· 1 shared Xiayan QiniD· 1 shared

Activity by Year

2026-2026 · peak 1/yr

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10 top collaborators · 45 mutual co-author links

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1 shared paperBiochemistry

Baihui TianORCID

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1 paper

Recent·Most cited

BiochemistrybioRxivPreprintJan 23, 2026

High-Affinity Protein Binder Design via Flow Matching and In Silico Maturation

Qilin Yu, Liangyue Guo, Xiayan Qin…·Mingchen Chen

This paper designs high-affinity protein binders using a computational framework combining flow matching and in silico maturation, achieving picomolar and nanomolar affinities without experimental screening.

3 citations

protein structuredeep learning

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