Author

Rachel Plumb

Pfizer (United States)ORCID 0000-0001-5329-5947Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Molecular Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 1 Assay:protein structure· 1 Research Focus:protein structure prediction· 1

Frequent Co-Authors

Chiachin Wilson Lee· 1 shared David R. Healy· 1 shared Erik C. Ralph· 1 shared Feng Wang· 1 shared Heather Wheeler· 1 shared Huixian WuiD· 1 shared Kevin W. HuynhiD· 1 shared Kimberly F. FennelliD· 1 shared

Activity by Year

2026-2026 · peak 1/yr

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10 top collaborators · 45 mutual co-author links

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1 shared paperMolecular Biology

Chiachin Wilson Lee

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1 paper

Recent·Most cited

Molecular BiologybioRxivPreprintFeb 12, 2026

Insight into the scaffolding function of USP18 from a high resolution cryo-EM structure of STAT2-USP18-ISG15 ternary complex

Kevin W. Huynh, Rachel Plumb, David R. Healy…·Masaya Yamaguchi

The paper determines the structure of the STAT2-USP18-ISG15 ternary complex using cryo-EM, revealing how USP18's scaffolding function suppresses IFN-I signaling by disrupting its enzymatic activity.

1 citation

protein structureexperimental assay

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