Author

Heather Wheeler

Pfizer (United States)

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

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Molecular Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 1 Assay:protein structure· 1 Research Focus:protein structure prediction· 1

Frequent Co-Authors

Chiachin Wilson Lee· 1 shared David R. Healy· 1 shared Erik C. Ralph· 1 shared Feng Wang· 1 shared Huixian WuiD· 1 shared Kevin W. HuynhiD· 1 shared Kimberly F. FennelliD· 1 shared Kymberly K. Levine· 1 shared

Activity by Year

2026-2026 · peak 1/yr

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10 top collaborators · 45 mutual co-author links

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1 shared paperMolecular Biology

Chiachin Wilson Lee

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1 paper

Recent·Most cited

Insight into the scaffolding function of USP18 from a high resolution cryo-EM structure of STAT2-USP18-ISG15 ternary complex

Kevin W. Huynh, Rachel Plumb, David R. Healy, Veronica Jové, Erik C. Ralph, Chiachin Wilson Lee, Heather Wheeler, Kymberly K. Levine, Zhen Huang, Kimberly F. Fennell, Richard A. Corpina, Timothy K. Craig, Paul D. Wes, Paula M. Loria, Monica Schenone, , Masaya Yamaguchi

The paper determines the structure of the STAT2-USP18-ISG15 ternary complex using cryo-EM, revealing how USP18's scaffolding function suppresses IFN-I signaling by disrupting its enzymatic activity.

bioRxiv · Feb 12, 2026 · PreprintMolecular Biology