Sustained poly(ADP-ribosyl)ation limits RPA loading and attenuates ATR-CHK1 signaling upon replication fork collapse
Alexandra Mihuț, Debanjan Ghosh, Dávid Szüts, Roberta Fajka‐Boja, Gyula Timinszky
This study shows that sustained PARylation reduces RPA loading and dampens ATR-CHK1 signaling during replication fork collapse, linking PARP activity to checkpoint control.
bioRxiv · Oct 22, 2025 · PreprintCell Biology