Cell BiologybioRxivPreprint
Sustained poly(ADP-ribosyl)ation limits RPA loading and attenuates ATR-CHK1 signaling upon replication fork collapse
Alexandra Mihuț, Debanjan Ghosh, Dávid Szüts…·Gyula Timinszky
This study shows that sustained PARylation reduces RPA loading and dampens ATR-CHK1 signaling during replication fork collapse, linking PARP activity to checkpoint control.
DOI 10.1101/2025.10.22.683893