Author

Alexandre Melnikov

Broad InstituteORCID 0000-0001-5346-1773Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Genomics· 2 Molecular Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Research Focus:benchmarking· 1 Research Focus:cell type annotation· 1 Research Focus:differential expression· 1 Organism:E. coli· 1 Organism:human· 1 Organism:mouse· 1 Organism:plant (other)· 1

Frequent Co-Authors

Peter RogoviD· 2 shared Andreas Gnirke· 1 shared Aung Pyae PhyoiD· 1 shared Aviv RegeviD· 1 shared Avrum E. SpiraiD· 1 shared Bruce W. BirreniD· 1 shared Cristin AubiniD· 1 shared Daniel E. NeafseyiD· 1 shared

Activity by Year

2014-2022 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 17 mutual co-author links

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2 shared papersGenomics

Peter RogovORCID

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3 papers

Recent·Most cited

GenomicsbioRxivPreprintAug 25, 2022

SnFFPE-Seq: towards scalable single nucleus RNA-Seq of formalin-fixed paraffin-embedded (FFPE) tissue

Hattie Chung, Alexandre Melnikov, Cristin Aubin…·Aviv Regev

The paper develops a method for single nucleus RNA-Seq from FFPE tissues and applies it to a human lung adenocarcinoma sample.

29 citations

𝕏 PostBluesky

GenomicsGenome biologyPeer-reviewedApr 28, 2017

Longitudinal genomic surveillance of Plasmodium falciparum malaria parasites reveals complex genomic architecture of emerging artemisinin resistance in western Thailand

Gustavo Coutinho Cerqueira, Ian H. Cheeseman, Stephen F. Schaffner…·Daniel E. Neafsey

The paper uses longitudinal genomic data from Plasmodium falciparum isolates in Thailand to identify genetic markers associated with artemisinin resistance, finding significant changes in SNPs beyond kelch13.

130 citationstop 1%

plant (other)whole-genome sequencing

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Molecular BiologybioRxivJun 10, 2014

Comprehensive mutational scanning of a kinase in vivo reveals substrate-dependent fitness landscapes

Alexandre Melnikov, Peter Rogov, Li Wang…·Tarjei S Mikkelsen

This study uses deep mutational scanning to show that fitness landscapes of a kinase depend on antibiotic structure and concentration, enabling the design of variants with orthogonal substrate specificities.

DOI 10.1093/nar/gku511

E. coliexperimental assay

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