The paper identifies a transcriptional profile in artemisinin-resistant Plasmodium falciparum that originates from initial drug responses and involves proteotoxic stress and REDOX metabolism.

1 citation

plant (other)bulk RNA-seq

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GenomicsGenome biologyPeer-reviewedApr 28, 2017

Longitudinal genomic surveillance of Plasmodium falciparum malaria parasites reveals complex genomic architecture of emerging artemisinin resistance in western Thailand

Gustavo Coutinho Cerqueira, Ian H. Cheeseman, Stephen F. Schaffner…·Daniel E. Neafsey

The paper uses longitudinal genomic data from Plasmodium falciparum isolates in Thailand to identify genetic markers associated with artemisinin resistance, finding significant changes in SNPs beyond kelch13.

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plant (other)whole-genome sequencing

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Evolutionary BiologybioRxivPreprintMay 24, 2015

Genomic epidemiology of the current wave of artemisinin resistant malaria

Roberto Amato, Olivo Miotto, Charles Woodrow…·MalariaGEN Plasmodium falciparum Community Project

This study identifies kelch13 mutations associated with artemisinin resistance in Southeast Asia and finds low frequency of these mutations in Africa, suggesting different evolutionary pressures.

DOI 10.1101/019737

plant (other)DNA methylation

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