Kathia Zaleta-Rivera

This study investigates how chromatin-associated RNA interacts with 3D genome organization in human cells, revealing a feedback loop between RNA distribution and chromatin structure.

This paper demonstrates that allele-specific RNAi therapy reduces disease-causing mutations in a mouse model of restrictive cardiomyopathy, improving cardiac function and reducing pathological markers.

This study compares two allele-specific silencing strategies in a human model of hypertrophic cardiomyopathy, finding that reducing both alleles improves contractility more than targeting only the disease allele.

The paper identifies PPP1R3A as a central cardioprotective factor in pressure overload heart failure by analyzing gene network rewiring in human hearts.