Beth L. Pruitt

E-cadherin mechanotransduction activates EGFR-ERK signaling in epithelial cells by inducing ADAM-mediated ligand shedding

This study shows mechanical strain activates EGFR-ERK signaling in epithelial cells via E-cadherin-induced ADAM17-mediated ligand shedding.

Spontaneous and Induced Oscillations in Confined Epithelia

The paper studies oscillations in epithelial cell trains, showing that spontaneous oscillations depend on cell train size and exhibit resonance when subjected to external deformations.

Stress relaxation rates of myocardium from failing and non-failing hearts

This study measures stress relaxation in myocardial tissue from failing and non-failing hearts, finding differences linked to fibrosis and fat accumulation.

YAP dysregulation triggers hypertrophy by CCN2 secretion and TGFβ uptake in human pluripotent stem cell-derived cardiomyocytes

This study shows that YAP overactivation in HCM mutant cardiomyocytes drives hypertrophy via CCN2 secretion and TGFβ uptake.

Multi-scale models reveal hypertrophic cardiomyopathy MYH7 G256E mutation drives hypercontractility and elevated mitochondrial respiration

This study investigates the effects of the MYH7 G256E mutation on myosin function across multiple scales, finding increased hypercontractility and mitochondrial respiration.

Touch-induced Mechanical Strain in Somatosensory Neurons is Independent of Extracellular Matrix Mutations in C. elegans

This study measures touch-induced mechanical strain in C. elegans neurons and finds no effect of ECM mutations on strain transmission.

Allele-specific silencing ameliorates restrictive cardiomyopathy due to a human myosin regulatory light chain mutation

This paper demonstrates that allele-specific RNAi therapy reduces disease-causing mutations in a mouse model of restrictive cardiomyopathy, improving cardiac function and reducing pathological markers.

Dissociation of disease phenotype and allele silencing in hypertrophic cardiomyopathy

This study compares two allele-specific silencing strategies in a human model of hypertrophic cardiomyopathy, finding that reducing both alleles improves contractility more than targeting only the disease allele.

Tissue mechanics and somatosensory neural responses govern touch sensation in C. elegans

This study develops a quantitative model to explain touch sensation in C. elegans by integrating tissue mechanics and neural responses to indentation stimuli.