Developmental BiologybioRxivPreprint
PAX4 loss of function alters human endocrine cell development and influences diabetes risk
Hwee Hui Lau, Nicole A. J. Krentz, Fernando Abaitua…·Adrian Kee Keong Teo
This study shows that PAX4 variants reduce beta cell function and increase diabetes risk by impairing insulin secretion and hormone gene expression in human cells.
1 citation