Alokkumar Jha

CardioWAS Pathway-Based RNA-Seq and Genome Integration Platform for CVD Omics-Wide Associations

CARDIOWAS integrates RNA-seq and GWAS data to identify disease-specific pathways in cardiovascular diseases, enabling pathway-level analysis and variant-pathway associations.

The role of inflammation in a humanized mouse model of transthyretin cardiac amyloidosis

This paper develops a humanized mouse model of V122I ATTR-CM and identifies inflammatory pathways involved in its pathogenesis.

Single cell multiome profiling of pancreatic islets reveals physiological changes in cell type-specific regulation associated with diabetes risk

The paper uses single-cell multiome profiling to identify gene regulatory changes in pancreatic islets linked to diabetes risk factors like age, sex, and genetic variants.

PAX4 loss of function alters human endocrine cell development and influences diabetes risk

This study shows that PAX4 variants reduce beta cell function and increase diabetes risk by impairing insulin secretion and hormone gene expression in human cells.

Metastatic Site Prediction in Breast Cancer using Kirchhoff's Law and Omics Knowledge Graph

This paper introduces Kirchhoff Knowledge Graphs (K-KG) to predict metastatic sites in breast cancer using multi-omics data, achieving high AUC and F1 scores.