Author

Benoite Champon

Centre for Human Genetics

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Developmental Biology· 1 Genetics· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Organism:human· 2 Assay:bulk RNA-seq· 1 Research Focus:differential expression· 1

Frequent Co-Authors

Anna L. GloyniD· 2 shared Fernando Abaitua· 2 shared Nicole A. J. KrentziD· 2 shared Adrian Kee Keong TeoiD· 1 shared Alokkumar JhaiD· 1 shared Andria Theodoulou· 1 shared Ann-Marie T. Richard· 1 shared Anthony J. PayneiD· 1 shared

Activity by Year

2019-2022 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 35 mutual co-author links

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2 shared papersDevelopmental Biology

Anna L. GloynORCID

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2 papers

Recent·Most cited

PAX4 loss of function alters human endocrine cell development and influences diabetes risk

Hwee Hui Lau, Nicole A. J. Krentz, Fernando Abaitua, Marta Perez‐Alcantara, Jun Wei Chan, Jila Ajeian, Soumita Ghosh, Benoite Champon, Han Sun, Alokkumar Jha, Shawn S. Hoon, Nguan Soon Tan, Daphne Su-Lyn Gardner, Shih Ling Kao, E Shyong Tai, , Adrian Kee Keong Teo

This study shows that PAX4 variants reduce beta cell function and increase diabetes risk by impairing insulin secretion and hormone gene expression in human cells.

bioRxiv · May 15, 2022 · PreprintDevelopmental Biology

Loss of ZnT8 function protects against diabetes by enhanced insulin secretion

Om Prakash Dwivedi, Mikko Lehtovirta, Benoît Hastoy, Vikash Chandra, Nicole A. J. Krentz, Sandra Kleiner, Deepak Jain, Ann-Marie T. Richard, Fernando Abaitua, Nicola L. Beer, Antje K. Grotz, Rashmi B. Prasad, Ola Hansson, Emma Ahlqvist, Ulrika Krus, , Leif Groop

The paper shows that a loss-of-function variant in ZnT8 improves insulin secretion and protects against type 2 diabetes by enhancing glucose responsiveness and proinsulin conversion.

Nature Genetics · Nov 1, 2019Peer-reviewedGenetics