Noushin Ghaffari

Genome in a Bottle benchmark of 12745 sequence-resolved insertions and deletions of 50 bp or more, integrating 19 calling methods, scores false negatives and false positives alike.

The paper shows BMAL1 DNA binding is tissue-specific and regulates rhythmic transcription through enhancer-enhancer interactions in the mouse liver.

The paper investigates factors affecting transcriptome assembly quality, finding that input RNA-Seq data quality and base-calling accuracy are more critical than coverage.