Jody Hey

The paper estimates the evolutionary fitness of all synonymous codon changes in Drosophila melanogaster using polymorphism data, finding weak but significant selection on codon usage.

This paper shows that accounting for global synonymous selection improves the accuracy of detecting episodic positive selection in protein evolution.

The paper introduces a new method to estimate mutation fitness effects by analyzing site frequency ratios, showing weak selection on synonymous sites in Drosophila populations.

The paper evaluates allele age estimators on whole exome datasets and finds a moderate performance decrease compared to whole genome data.

The paper develops MSS models to estimate selection on synonymous substitutions, finding significant correlations with covariates of codon usage selection across Drosophila species.

The Pop-gen Pipeline Platform provides a standardized software solution to streamline population genomic analyses by automating workflows and reducing computational barriers.

The paper estimates the age of rare alleles using haplotype sharing to infer demographic history and selection pressures in a UK population.

The paper estimates recent African gene flow into the UK population, identifying old rare variants that suggest a 1.2% contribution approximately 400 years ago.