Systems BiologybioRxivPreprint
Single-Cell and Spatial Multi-omics Reveal Interferon Signaling in the Pathogenesis of Perianal Fistulizing Crohn's Disease
Siyan “Stewart” Cao, Khai M. Nguyen, Kaiming Ma…·Parakkal Deepak
The paper uses multi-omics approaches to identify hyperactivated IFNG signaling in PCD, linking it to immune and stromal cell pathogenesis and suggesting IFNG as a therapeutic target.