Author

Parakkal Deepak

Washington University in St. LouisORCID 0000-0002-3436-9784Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Cell Biology· 2 Immunology· 1 Systems Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Research Focus:cell type annotation· 2 Research Focus:chromatin & epigenetic regulation· 2 Research Focus:differential expression· 2 Assay:DNA methylation· 2 Organism:human· 2 Organism:mouse· 2 Assay:proteomics· 2

Frequent Co-Authors

Anas K. Gremida· 2 shared Anuj Shukla· 2 shared George Koshkaryan· 2 shared Gregory Mh· 2 shared Henning Jacob JesseniD· 2 shared Kaiming MaiD· 2 shared Katherine Huang· 2 shared Kayci Huff-Hardy· 2 shared

Activity by Year

2024-2026 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 36 mutual co-author links

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2 shared papersCell Biology

Anas K. Gremida

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Author profile →

4 papers

Recent·Most cited

Novel mouse models for perianal fistulizing Crohns disease reveal therapeutic value of interferon-gamma antagonists

Xin Yao, Kaiming Ma, David H. Ballard, Echo Zhu, Xiuli Liu, Lingjie Huang, Chuwen Tian, James D. Quirk, Heather S. Ruiz, Tingyi Tan, Matthew A. Ciorba, Gwendalyn J. Randolph, Parakkal Deepak, Siyan Cao

This study develops mouse models of perianal fistulizing Crohn's disease and identifies IFN-gamma signaling as a therapeutic target.

bioRxiv · Jun 8, 2026 · PreprintImmunology

Fasting disrupts the InsP6 HDAC3 axis to drive ER stress-mediated clearance of DNA-damaged cells and enforce tissue quality control.

Sujan Chetterjee, Zachary Sin, Richard Van, Nguyen Tran, Tam Tran, Anuj Shukla, Lucile M. Jeusset, George Koshkaryan, Kevin Saldana, Rayan Muneer, Loretta Viera Preval, Lingkun Gu, Faizan Bhat, Kevin Ritter, Katherine Huang, , Prasun Guha

The paper shows that fasting disrupts the TGF-β-InsP6-HDAC3 axis, inducing ER stress and eliminating DNA-damaged cells to maintain tissue quality.

bioRxiv · May 27, 2026 · PreprintCell Biology

Phytic Acid (InsP6) Activates HDAC3 Epigenetic Axis to Maintain Intestinal Barrier Function

Sujan Chatterjee, Zachary Sin, Nguyen Tran, Loretta Viera Preval, Anuj Shukla, Tam Tran, George Koshkaryan, Kevin Ritter, Xue Bessie Su, Saharat Jolak Ragsac, Seungman Park, Qian Liu, Richard Van, Katherine Huang, Kayci Huff-Hardy, , Prasun Guha

The paper shows that phytic acid activates the HDAC3 epigenetic axis to maintain intestinal barrier function, with therapeutic potential in inflammatory bowel disease.

Nature Communications · Feb 9, 2026Peer-reviewedCell Biology

Single-Cell and Spatial Multi-omics Reveal Interferon Signaling in the Pathogenesis of Perianal Fistulizing Crohn's Disease

Siyan “Stewart” Cao, Khai M. Nguyen, Kaiming Ma, Xin Yao, Ta‐Chiang Liu, Malek Ayoub, Jalpa Devi, Yizhou A. Liu, Radhika K. Smith, Matthew L. Silviera, Steven R. Hunt, Paul E. Wise, Matthew G. Mutch, Sean Christopher Glasgow, William C. Chapman, , Parakkal Deepak

The paper uses multi-omics approaches to identify hyperactivated IFNG signaling in PCD, linking it to immune and stromal cell pathogenesis and suggesting IFNG as a therapeutic target.

bioRxiv · Nov 8, 2024 · PreprintSystems Biology