Author

Malek Ayoub

Washington University in St. LouisORCID 0009-0008-6972-170XUnclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Systems Biology· 1

Signature Assays, Organisms & Methods

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Research Focus:cell type annotation· 1 Assay:CITE-seq· 1 Research Focus:differential expression· 1 Approach:experimental assay· 1 Research Focus:gene regulatory network inference· 1 Organism:human· 1 Assay:scRNA-seq· 1 Assay:spatial transcriptomics· 1

Frequent Co-Authors

Jalpa DeviiD· 1 shared Kaiming MaiD· 1 shared Khai M. NguyeniD· 1 shared Marco ColonnaiD· 1 shared Mathew A. Ciorba· 1 shared Matthew G. MutchiD· 1 shared Matthew L. Silviera· 1 shared Michelle L. Cowan· 1 shared

Activity by Year

2024-2024 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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1 shared paperSystems Biology

Jalpa DeviORCID

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1 paper

Recent·Most cited

Single-Cell and Spatial Multi-omics Reveal Interferon Signaling in the Pathogenesis of Perianal Fistulizing Crohn's Disease

Siyan “Stewart” Cao, Khai M. Nguyen, Kaiming Ma, Xin Yao, Ta‐Chiang Liu, Malek Ayoub, Jalpa Devi, Yizhou A. Liu, Radhika K. Smith, Matthew L. Silviera, Steven R. Hunt, Paul E. Wise, Matthew G. Mutch, Sean Christopher Glasgow, William C. Chapman, , Parakkal Deepak

The paper uses multi-omics approaches to identify hyperactivated IFNG signaling in PCD, linking it to immune and stromal cell pathogenesis and suggesting IFNG as a therapeutic target.

bioRxiv · Nov 8, 2024 · PreprintSystems Biology