Gabriel A. Gonzalez

The paper uses a genomic language model to cluster and annotate noncoding sequences in prokaryotic genomes, identifying structured RNAs and their potential functions.

This paper describes the engineering of IS622 bridge recombinases to enable efficient and specific DNA rearrangements in the human genome, including insertion, inversion, and excision of up to 0.93 megabases.

A 40B-parameter DNA model trained on 9.3 trillion tokens scores coding and noncoding variants zero-shot, exposes interpretable sequence features, and writes chromosome-scale sequences.