Author

Enrique Lin-Shiao

University of California, San FranciscoORCID 0000-0001-5396-9614Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Genetics· 1

Signature Assays, Organisms & Methods

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Research Focus:cell-cell communication· 1 Assay:CRISPR screen· 1 Research Focus:drug response / drug discovery· 1 Approach:experimental assay· 1 Research Focus:gene regulatory network inference· 1 Organism:human· 1 Research Focus:variant calling· 1

Frequent Co-Authors

David ColognoriiD· 1 shared Evelyn CheniD· 1 shared Jennifer A. DoudnaiD· 1 shared Marena I. TrinidadiD· 1 shared Mohammad Saffari DoostiD· 1 shared

Activity by Year

2022-2022 · peak 1/yr

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5 top collaborators · 10 mutual co-author links

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1 shared paperGenetics

David ColognoriORCID

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1 paper

Recent·Most cited

GeneticsProceedings of the National Academy of SciencesPeer-reviewedDec 2, 2022

Decorating chromatin for enhanced genome editing using CRISPR-Cas9

Evelyn Chen, Enrique Lin-Shiao, Marena I. Trinidad…·Jennifer A. Doudna

This study enhances CRISPR-Cas9-mediated HDR efficiency by fusing Cas9 with PRDM9, increasing HDR by three-fold and HDR:indel ratio by five-fold without increasing off-target effects.

54 citations

humanCRISPR screen

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