Evelyn Chen

This study identifies tumor-intrinsic stress states as modulators of CAR T cell therapy response in pancreatic cancer using CRISPR screens and single-cell genomics.

This study enhances CRISPR-Cas9-mediated HDR efficiency by fusing Cas9 with PRDM9, increasing HDR by three-fold and HDR:indel ratio by five-fold without increasing off-target effects.

The paper demonstrates programmable enveloped delivery vehicles (EDVs) that enable cell-specific genome editing in vivo and ex vivo by targeting CRISPR-Cas9 to specific cell types.