Author

Jacob P. Sieg

Pennsylvania State UniversityORCID 0000-0001-5414-1667Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Research Focus:differential expression· 1 Approach:experimental assay· 1 Research Focus:gene regulatory network inference· 1 Organism:human· 1 Assay:long-read sequencing· 1 Approach:machine learning (classical)· 1 Organism:non-human primate· 1 Approach:statistical model· 1

Frequent Co-Authors

Kateryna D. MakovaiD· 2 shared Angelika LahnsteineriD· 1 shared Francesca ChiaromonteiD· 1 shared Hana PálováiD· 1 shared Huiqing Zeng· 1 shared Huqing Zeng· 1 shared Lauren Heaverly· 1 shared Linnéa SmedsiD· 1 shared

Activity by Year

2025-2026 · peak 1/yr

Co-Author Collaboration Network

9 top collaborators · 24 mutual co-author links

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2 shared papersBioinformatics

Kateryna D. MakovaORCID

Mutual co-authors in cluster

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2 papers

Recent·Most cited

BioinformaticsbioRxivPreprintJul 18, 2026

Direct detection of alternative DNA conformations with long-read sequencing and machine learning approaches

Jacob P. Sieg, Huqing Zeng, Lauren Heaverly, Kateryna D. Makova

This study uses long-read sequencing and machine learning to detect alternative DNA conformations, achieving ~90% accuracy in distinguishing G4 from B-form DNA.

DOI 10.64898/2026.07.17.739277

long-read sequencingmachine learning (classical)

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GenomicsbioRxivPreprintNov 3, 2025

Comparative analysis of single-stranded and non-canonical DNA formation in human and other ape cells with telomere-to-telomere genomes

Jacob P. Sieg, Huiqing Zeng, Hana Pálová…·Kateryna D. Makova

The paper analyzes single-stranded DNA (ssDNA) formation in human and non-human ape telomere-to-telomere genomes to identify non-B DNA structures and their functional roles.

1 citation

humannon-human primate

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