Author

Horst K. Wallrabe

University of Virginia

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Neuroscience· 2

Signature Assays, Organisms & Methods

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Research Focus:differential expression· 2 Approach:experimental assay· 2 Organism:human· 2 Assay:imaging· 2 Organism:mouse· 2 Assay:bulk RNA-seq· 1 Research Focus:cell type annotation· 1 Research Focus:cell-cell communication· 1

Frequent Co-Authors

Ammasi PeriasamyiD· 2 shared Andrés NorambuenaiD· 2 shared Evelyn PardoiD· 2 shared George S. BloomiD· 2 shared Xuehan SuniD· 2 shared Dora Bigler Wang· 1 shared Garnett A. Mingledorff· 1 shared Heather Anne FerrisiD· 1 shared

Activity by Year

2022-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 39 mutual co-author links

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2 shared papersNeuroscience

Ammasi PeriasamyORCID

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2 papers

Recent·Most cited

Mitochondrial NADK2-dependent NADPH controls Tau oligomer uptake in human neurons

Evelyn Pardo, Taylor Kim, Horst K. Wallrabe, Kristine E. Zengeler, Vijay Kumar Sagar, Garnett A. Mingledorff, Xuehan Sun, Ammasi Periasamy, John R. Lukens, George S. Bloom, Andrés Norambuena

The paper shows that mitochondrial NADK2-dependent NADPH synthesis mediates Tau oligomer uptake in neurons via LRP1, creating a cycle that exacerbates TauO toxicity.

Alzheimer s & Dementia · Jun 1, 2026Peer-reviewedNeuroscience

SOD1 Mediates Lysosome-to-Mitochondria Communication and its Dysregulation by Amyloid-β Oligomers

Andrés Norambuena, Xuehan Sun, Horst K. Wallrabe, Ruofan Cao, Naidi Sun, Evelyn Pardo, Nutan Shivange, Dora Bigler Wang, Lisa A. Post, Heather Anne Ferris, Song Hu, Ammasi Periasamy, George S. Bloom

The paper identifies SOD1 as a mediator of lysosome-to-mitochondria communication and shows its dysregulation by amyloid-β oligomers in Alzheimer's disease.

Neurobiology of Disease · Apr 20, 2022Peer-reviewedNeuroscience