Olivia S. Smith

Across UK Biobank, All of Us and FinnGen, the inferred mean direction (sign bias) of rare minor-allele effects varies and is largely explained by each cohort's trait skewness.

This paper investigates the portability of polygenic scores across genetic and demographic differences, identifying three key gaps in understanding.

This paper highlights how confounding factors lead to misinterpretation in genetic studies of human behavior and socioeconomic outcomes by reanalyzing two examples.

This paper introduces PGSUS, a method to assess the influence of stratification and assortative mating effects on polygenic scores, revealing that direct genetic effects often contribute little to PGS variation.

The paper uses deep learning on DXA images to identify genetic variants affecting skeletal proportions and links these to evolutionary changes and disease risk.