Jedidiah Carlson

This paper highlights how confounding factors lead to misinterpretation in genetic studies of human behavior and socioeconomic outcomes by reanalyzing two examples.

This study quantifies sex-differential selection (SDS) across the human genome using UK Biobank data, revealing polygenic signals and a tradeoff between viability and fecundity.

Over 400 million variants, 97% below 1% frequency, emerge from deep whole-genome sequencing of 53,831 diverse TOPMed participants; TOPMed haplotypes enable imputation down to ~0.01% frequency.

The paper analyzes rare variants to uncover mutation rate heterogeneity in the human genome, identifying genomic features that influence mutation rates.

Helmsman generates mutation spectra matrices efficiently, enabling mutation signature analysis on large datasets with high speed and low memory usage.