Author

Jared M. Cole

The University of Texas at AustinORCID 0000-0002-0339-2973Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Genomics· 2 Evolutionary Biology· 1

Signature Assays, Organisms & Methods

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Organism:human· 3 Approach:statistical model· 3 Research Focus:GWAS / association mapping· 2 Assay:GWAS summary statistics· 2 Assay:whole-genome sequencing· 2 Approach:Bayesian inference· 1 Assay:electronic health records· 1 Approach:simulation· 1

Frequent Co-Authors

Arbel HarpakiD· 3 shared Mark KirkpatrickiD· 2 shared Matthew J. MingiD· 2 shared Carly B. ScottiD· 1 shared Carrie ZhuiD· 1 shared Jedidiah CarlsoniD· 1 shared Mackenzie M. JohnsoniD· 1 shared Michael D. EdgeiD· 1 shared

Activity by Year

2023-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 29 mutual co-author links

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3 shared papersGenomics

Arbel HarpakORCID

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

Representation in genetic studies affects inference about genetic architecture

Jared M. Cole, Shane Rybacki, Samuel Pattillo Smith, Olivia S. Smith, Arbel Harpak

Across UK Biobank, All of Us and FinnGen, the inferred mean direction (sign bias) of rare minor-allele effects varies and is largely explained by each cohort's trait skewness.

bioRxiv · Aug 19, 2026 · PreprintGenomics✦ In-depth digest

The battle of the sexes in humans is highly polygenic

Jared M. Cole, Carly B. Scott, Mackenzie M. Johnson, Peter R. Golightly, Jedidiah Carlson, Matthew J. Ming, Arbel Harpak, Mark Kirkpatrick

This study quantifies sex-differential selection (SDS) across the human genome using UK Biobank data, revealing polygenic signals and a tradeoff between viability and fecundity.

Proceedings of the National Academy of Sciences · Sep 20, 2024Peer-reviewedEvolutionary Biology

Amplification is the Primary Mode of Gene-by-Sex Interaction in Complex Human Traits

Carrie Zhu, Matthew J. Ming, Jared M. Cole, Michael D. Edge, Mark Kirkpatrick, Arbel Harpak

The paper identifies amplification as the main mechanism of gene-by-sex interactions in complex human traits, showing sex differences in genetic effect magnitudes rather than variant identity.

Cell Genomics · Apr 6, 2023Peer-reviewedGenomics