The effect of increased CpG and UpA dinucleotides in the West Nile virus genome on virus transmission by Culex mosquitoes and pathogenesis in a vertebrate host
Joyce W. M. van Bree, Imke Visser, Eleanor M. Marshall, Wessel Willemsen, Carmen van de Waterbeemd, Dennis Kenbeek, Marleen H. C. Abma-Henkens, Gorben P. Pijlman, Monique M. van Oers, Barry Rockx, Jelke Jan Fros
This study examines how increasing CpG and UpA dinucleotides in West Nile virus affects replication in mosquitoes and vertebrates, showing differential attenuation and neuroinvasiveness outcomes.
Journal of Virology · Sep 8, 2025Peer-reviewedMicrobiology