A. P. Jason de Koning

Apollo simulates within-host viral evolution and infection dynamics, validating limitations of transmission inference tools using HIV cohort data.

The paper reports a novel MFN2 variant associated with ataxia, optic atrophy, and sensorineural hearing loss, and shows its functional impact in patient fibroblasts.

The paper clarifies that Haldane's probability of mutant survival is not the same as allele establishment probability, showing it is 4s under certain assumptions.

The paper shows that the neutral molecular clock rate depends on population size and mutation rate, contradicting classical theory under strong mutation pressures.