Gwen Alyce Lomberk

This study analyzes molecular dynamics of hBD-1 variants to identify perturbation signatures and prioritize variants for structure-function testing.

This study shows that KRAS inhibition can reverse chemotherapy resistance in PDAC by targeting therapy-induced senescence-like cells, with ERK pathway involvement.

This paper classifies EHMT1 variants into structural, dynamic, and combined structural-dynamic categories using computational methods to improve variant interpretation for Kleefstra syndrome.

The paper uses molecular dynamics simulations to analyze 86 KRAS mutations, revealing mutation-specific conformations and functional insights not captured by current genomic tools.

The paper identifies a novel alternatively spliced HP1g isoform, sHP1g, lacking the chromoshadow domain, and shows its expression across tissues and dysregulation in cancers.