Author

Patricia Santofimia‐Castaño

Centre National de la Recherche ScientifiqueORCID 0000-0003-2506-5567Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Cancer Biology· 1 Cell Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Organism:human· 2 Assay:proteomics· 2 Assay:bulk RNA-seq· 1 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:cell type annotation· 1 Research Focus:chromatin & epigenetic regulation· 1

Frequent Co-Authors

Juan IovannaiD· 2 shared Analía Meilerman Abuelafia· 1 shared Daniel GrassoiD· 1 shared Eduardo ChuluyániD· 1 shared Gwen Alyce LomberkiD· 1 shared Jessica NouwsiD· 1 shared John E. McDonoughiD· 1 shared Maor SauleriD· 1 shared

Activity by Year

2025-2025 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 27 mutual co-author links

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2 shared papersCancer Biology

Juan IovannaORCID

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2 papers

Recent·Most cited

Cancer BiologyTranslational OncologyPeer-reviewedMay 17, 2025

KRAS Inhibition Reverses Chemotherapy Resistance Promoted by Therapy-Induced Senescence-like in Pancreatic Ductal Adenocarcinoma

Analía Meilerman Abuelafia, Patricia Santofimia‐Castaño, Matías Estarás…·Juan Iovanna

This study shows that KRAS inhibition can reverse chemotherapy resistance in PDAC by targeting therapy-induced senescence-like cells, with ERK pathway involvement.

6 citations

humanbulk RNA-seq

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Cell BiologybioRxivPreprintApr 27, 2025

The ferroptosis inhibitor NUPR1 coordinates the mitochondrial response to oxidative stress and cell metabolism during COPD pathogenesis in the lung

Saul S. Siller, Tao Yang, Jessica Nouws…·Maor Sauler

This study shows NUPR1 inhibition worsens oxidative stress, mitochondrial dysfunction, and metabolic imbalance in COPD, linking it to ferroptosis and disease progression.

DOI 10.1101/2025.04.27.650854

mousehuman

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