Philip J. Cowen

This study examines how ketamine affects emotional evidence integration in changing environments, finding it shifts the balance between recent and past information based on volatility.

This study shows ketamine reduces habenula activity during aversive learning in humans, supporting preclinical findings on its antidepressant mechanisms.

The paper identifies a hippocampal metabolic signature linked to mood and insulin signalling in depression, showing conserved effects across humans and mice.

This study shows how increased synaptic histamine affects hippocampal dynamics and learning by using a causal probe and analyzing neurocomputational strategies.

This study uses a selective serotonin releasing agent to examine how increased synaptic serotonin affects decision-making in aversive contexts, finding reduced sensitivity to aversive outcomes and enhanced impulse control.

This study finds elevated peripheral C-reactive protein (CRP) is associated with treatment-resistant depression, childhood adversity, and specific depressive and anxious symptoms.