Jonathan Cavanagh

This study shows that peripheral inflammation triggers fat pad atrophy and lymph node expansion via macrophage activity, supporting immune response energy needs.

This study investigates neuroinflammation in mice driven by TLR7 activation, finding global immune activation and region-specific neuronal gene expression changes in mood-related brain areas.

This study identifies thalamostriatal circuit disruption as a conserved neuroinflammatory mechanism linking systemic inflammation to depression and anhedonia in humans and mice.

This study compares the effects of TLR3 and TLR7 agonists on maternal blood, placenta, and fetal brain in mice, revealing distinct immune responses and implications for schizophrenia risk.

The paper investigates the synaptic connections of the nucleus reuniens to hippocampal CA1 and finds that it preferentially targets inhibitory interneurons rather than pyramidal cells.

The paper investigates associations between APOE genotypes and blood biomarkers in UK Biobank, finding both expected and unexpected links to AD risk factors.

This paper uses machine learning to predict one-year employment, education, or training (EET) status and symptom remission in first episode psychosis patients, achieving high accuracy in external validation.

This study identifies genetic loci associated with circadian rhythmicity using UK Biobank data and finds polygenic associations with mood instability and major depressive disorder.

This study finds elevated peripheral C-reactive protein (CRP) is associated with treatment-resistant depression, childhood adversity, and specific depressive and anxious symptoms.

This study identifies genetic loci associated with risk-taking behavior and finds shared genetic risk with several psychiatric and physical disorders using UK Biobank data.

The paper examines the association between APOE e4 genotype and brain structural ageing phenotypes in UK Biobank, finding a significant link with white matter hyperintensity volumes but no age interaction.

This study identifies dorsomedial prefrontal cortex activity patterns during reinforcement learning that predict response to computerised CBT in depression.

The paper combines GWAS, clinical data, and experimental models to identify JAK-STAT pathway dysregulation as a potential therapeutic target for Alzheimer’s disease.