NeurosciencebioRxivPreprint
PIP2 electrostatically triggers vesicle fusion: arresting full SNARE assembly and vesicle fusion by PIP2-masking
Houda Yasmine Ali Moussa, Kyung Chul Shin, Janarthanan Ponraj…·Yongsoo Park
The paper shows that MARCKS masks PIP2, arresting SNARE assembly and vesicle fusion, while PIP2 unmasking by Ca2+/CaM or PKC-epsilon rescues fusion and enhances synaptotagmin-1 activity.
DOI 10.1101/2023.05.28.542642