Yongsoo Park

This study creates a zebrafish model of NAPB knockout to study autism and epilepsy, finding hyperactivity and hyperexcitability resembling human epileptic encephalopathy.

This study examines immune responses in craft and manual workers after a BNT162b2 booster, showing enhanced Th1 and cytotoxic T cell responses, and durable humoral immunity, with prior infection boosting B cell counts.

The paper shows that MARCKS masks PIP2, arresting SNARE assembly and vesicle fusion, while PIP2 unmasking by Ca2+/CaM or PKC-epsilon rescues fusion and enhances synaptotagmin-1 activity.

The paper investigates how Ca2+ and chelators like ATP and EGTA regulate the cis- and trans-membrane interactions of synaptotagmin-1 using purified vesicles and liposomes.

This study shows that deleting TRPC6 in human cortical neurons increases neuronal hyperexcitability by reducing SOCE signaling.

This study shows cholesterol is required for Ca2+-dependent vesicle fusion by stabilizing synaptotagmin-1-induced membrane bending.

The paper uses next-generation sequencing and synthetic neurotransmission to show that large dense-core vesicles contain miRNAs and that miRNA exocytosis is mediated by SNARE and accelerated by Ca2+.