Author

Jessica L. Bonnar

Howard Hughes Medical InstituteORCID 0000-0001-5531-4849Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Organism:human· 2 Assay:CRISPR screen· 1 Research Focus:differential expression· 1 Approach:experimental assay· 1 Research Focus:gene regulatory network inference· 1 Research Focus:perturbation response prediction· 1 Assay:scRNA-seq· 1 Approach:statistical model· 1

Frequent Co-Authors

Alina GunaiD· 2 shared Angela N. PogsoniD· 2 shared Jonathan S. WeissmaniD· 2 shared Joseph M. ReplogleiD· 2 shared Marco JostiD· 2 shared Thomas M. NormaniD· 2 shared Alexander LeNailiD· 1 shared Baylee J. RusselliD· 1 shared

Activity by Year

2022-2022 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 42 mutual co-author links

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2 shared papersGenomics

Alina GunaORCID

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2 papers

Recent·Most cited

GenomicseLifePeer-reviewedDec 28, 2022

Maximizing CRISPRi efficacy and accessibility with dual-sgRNA libraries and optimal effectors

Joseph M. Replogle, Jessica L. Bonnar, Angela N. Pogson…·Marco Jost

This paper develops compact CRISPRi sgRNA libraries and optimal effectors to improve knockdown consistency and efficiency in mammalian cells.

152 citationstop 1%

humanCRISPR screen

𝕏 PostBluesky

GenomicsCellPeer-reviewedJun 9, 2022

Mapping information-rich genotype-phenotype landscapes with genome-scale Perturb-seq

Joseph M. Replogle, Reuben A. Saunders, Angela N. Pogson…·Jonathan S. Weissman

The paper performs genome-scale Perturb-seq to map genotype-phenotype relationships, uncovering new gene functions and stress-specific mitochondrial regulation.

727 citationstop 1%

𝕏 PostBluesky