Author

Mitra‐Sadat Sadat‐Shirazi

Tufts UniversityORCID 0000-0002-1905-2500Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Research Focus:differential expression· 1 Assay:DNA methylation· 1 Approach:experimental assay· 1 Organism:human· 1 Organism:mouse· 1 Approach:statistical model· 1

Frequent Co-Authors

Alexandre ChamprouxiD· 2 shared Larry A. FeigiD· 2 shared Abigail KaijaiD· 1 shared Aidan Chen· 1 shared Arturo HernándeziD· 1 shared Denny SakkasiD· 1 shared Emily MelleniD· 1 shared Jonathan HackeriD· 1 shared

Activity by Year

2025-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 38 mutual co-author links

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2 shared papersGenetics

Alexandre ChamprouxORCID

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2 papers

Recent·Most cited

Exposure of Men to PTSD-Promoting Trauma Elevates Levels of Sperm miRNAs with Anxiety and Depression-Inducing Activities

Mitra‐Sadat Sadat‐Shirazi, Alexandre Champroux, Aidan Chen, Denny Sakkas, Tammy Maria Scott, Emily Mellen, Abigail Kaija, Larisa Ryzhova, Lucy Liaw, Arturo Hernández, Larry A. Feig

This study finds that men exposed to trauma have elevated sperm miRNAs linked to anxiety and depression in offspring, though not all trauma-exposed men show increased anxiety or depression themselves.

bioRxiv · Apr 27, 2026 · PreprintGenetics

Astrocyte-Derived Exosomes Regulate Sperm miR-34c Levels to Mediate the Transgenerational Effects of Paternal Chronic Social Instability Stress

Alexandre Champroux, Mitra‐Sadat Sadat‐Shirazi, Xuan Chen, Jonathan Hacker, Yongjie Yang, Larry A. Feig

This study shows that paternal chronic social instability stress reduces sperm miR-34c levels via astrocyte-derived exosomes, which are transmitted to offspring and contribute to transgenerational stress-related traits.

Epigenetics · Jan 27, 2025Peer-reviewedGenetics