Author

Tomohito Higashi

Fukushima Medical UniversityORCID 0000-0001-5616-1477Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Research Focus:cell signaling & trafficking· 2 Approach:experimental assay· 2 Assay:imaging· 2 Organism:Xenopus· 2 Research Focus:cell type annotation· 1 Research Focus:development & morphogenesis· 1 Organism:mouse· 1 Assay:proteomics· 1

Frequent Co-Authors

Alexander ChangiD· 1 shared Ann Louise MilleriD· 1 shared Atsuko Y. HigashiiD· 1 shared Babli AdhikaryiD· 1 shared Brian J. MitchelliD· 1 shared Eve E Suva· 1 shared Hideki ChibaiD· 1 shared

Activity by Year

2026-2026 · peak 2/yr

Co-Author Collaboration Network

7 top collaborators · 11 mutual co-author links

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1 shared paperCell Biology

Alexander ChangORCID

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2 papers

Recent·Most cited

Cell BiologyThe Journal of Cell BiologyPeer-reviewedJul 20, 2026

PAK4 promotes vertex remodeling to maintain epithelial integrity and barrier function

Babli Adhikary, Alexander Chang, Atsuko Y. Higashi…·Tomohito Higashi

This study shows PAK4 and Afadin cooperate to maintain epithelial integrity by promoting vertex remodeling, with PAK4 inhibition disrupting junctional continuity and barrier function.

2 citations

mouseXenopus

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Cell BiologybioRxivPreprintJun 6, 2026

Sidekick2 facilitates multiciliated cell penetration through multicellular adherens junctions

Eve E Suva, Tomohito Higashi, Brian J. Mitchell

This study shows Sidekick2 facilitates multiciliated cell penetration through multicellular adherens junctions during radial intercalation in Xenopus laevis.

DOI 10.64898/2026.06.03.729971

Xenopusimaging

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