S Lawrence Zipursky

The paper identifies LC17 neurons and their electrical synapses as critical for visual approach behavior in fruit flies.

The paper shows that the L2/3 continuum in the mouse visual cortex develops through two phases: a genetically programmed initial phase and a visually experience-driven second phase.

The paper uses spatial transcriptomics and computational methods to show that vision affects both cell state and cell type composition in the visual cortex during critical periods.

The paper identifies molecular gradients in Drosophila neurons that regulate synaptic connectivity for visuomotor transformation.

The paper develops a method to tag endogenous GPCRs in Drosophila for localization studies and uses it to investigate receptor distribution and function in neural circuits.

The paper maps neurotransmitter receptor subtypes and protein complexes to synapses in Drosophila using molecular and connectomic techniques.

The paper identifies synaptic specificity determinants by integrating connectomes and transcriptomes in Drosophila.

The paper shows that the Ecdysone pathway regulates timing of transcription factor expression, which in turn controls cell-type specific wiring programs in fly neurons.

The paper shows that vision selectively drives the specification of upper-layer glutamatergic cell types in the mouse visual cortex through gene expression regulation.

This study shows that vision is required for forming binocular neurons and improving their tuning before the classical critical period.

The paper shows vision transforms unstable binocular circuitry into a network of highly tuned complex feature detectors in layer 2/3 of the cortex.

The paper identifies modular transcriptional programs that independently control dendritic and axonal connectivity in Drosophila T4/T5 neurons.