Olivia Sheppard

This study shows that lowering glucose increases Aβ levels in mouse brain slices and human cells, likely via BACE1 activation, but not in hypoxia conditions.

The paper investigates whether tau assemblies behave like independently acting prion-like particles in mouse neural tissue and finds that seeding behavior only occurs at supra-physiological concentrations.

This study shows that BACE1 inhibition reduces excessive vascular sprouting in AD by restoring NOTCH3 signaling and normalizing endothelial filopodia formation.

This study develops an organotypic hippocampal slice culture model of neuroinflammation and shows that LPS-induced synaptophysin loss depends on microglia and IL1β.