Hong Li

This study profiles early hepatocellular carcinomas to reveal molecular mechanisms of malignancy transition, identifying TERT alterations, CNA burden, and immune evasion as key factors.

This study identifies Caspase-8-mediated CYLD cleavage as a mechanism promoting LPS-induced endotoxic shock and reveals CP25 as a potential biomarker.

scMagnify decomposes multi-scale gene regulatory networks from single-cell multiomics data, revealing regulatory logic in development and disease.

SPCoral integrates spatial multi-omics data across different modalities and technologies, improving spatial domain identification and cross-modal analysis.

SOAPy is a Python package that analyzes spatial omics data to study spatial architecture, dynamics, and communication across various biological contexts.

This paper introduces JointSyn, a dual-view learning method for predicting drug synergy, showing improved accuracy and generalization across datasets.

This study performs genome assembly and transcriptome analysis of Microtus fortis to understand its resistance to Schistosoma japonicum infection, revealing differences in immune response timing and effectiveness compared to mice.

DComboNet prioritizes effective anti-cancer drug combinations using a two-level network model, achieving high AUC performance and inferring potential combination mechanisms.