Heather Brockway

The paper constructs a genome-scale transcriptional regulatory network of the human placenta using genomic and transcriptomic data, identifying key regulators of preterm birth.

This study shows that HAND1 knockdown affects gene expression in trophoblast cells but not endothelial cells, highlighting the importance of extra-embryonic tissue in CHD research.

The paper identifies potential targeting moieties for placental therapeutics by comparing proteomes of normal and intrauterine growth restricted placentas.

The paper identifies unique transcriptomic signatures in idiopathic spontaneous and infection-related preterm births compared to normal term births, highlighting differences in IGF signaling and inflammation.