Suhas G. Kallapur

Anakinra reduced preterm labor and inflammation in a Rhesus macaque model of E. coli-induced intrauterine infection.

This study evaluates manual gating, unsupervised clustering, and auto-gating methods for high-dimensional cytometry data using six datasets and provides practical guidelines for selecting appropriate methods.

This study uses single-nucleus RNA-seq to show that chorioamnionitis disrupts cerebellar cell maturation in preterm nonhuman primates, leading to Purkinje cell loss and altered granule and oligodendrocyte development.

This study shows that blocking inflammation in preterm primates prevents lung injury, preserving alveolar structure and function similar to chronic lung disease in newborns.

The paper identifies unique transcriptomic signatures in idiopathic spontaneous and infection-related preterm births compared to normal term births, highlighting differences in IGF signaling and inflammation.